Allergy to beta-lactam antibiotics in children: predictors for a positive oral challenge test (2024)

1. http://orcid.org/0000-0002-4265-1966Amanda L Wilkins1,2,3,
2. Laure F Pittet4,5,6,
3. Sophie Kyriakou2,7,
4. Kimberly Walker2,
5. Susan Donath3,8,
6. Sharon Choo9,
7. Noel Cranswick1,3,10,
8. Amanda Gwee1,2,3,11

1. ¹Department of General Medicine, Royal Children's Hospital, Parkville, Victoria, Australia
2. ²Antimicrobials Group, Murdoch Children's Research Institute, Parkville, Victoria, Australia
3. ³Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia
4. ⁴Infectious Diseases Group, Murdoch Children’s Research Institute, Parkville, Victoria, Australia
5. ⁵Department of Infectious Diseases, The Royal Children's Hospital, Parkville, Victoria, Australia
6. ⁶Infectious Diseases Unit, Department of Paediatrics, Gynaecology and Obstetrics, Faculty of Medicine, University of Geneva and University Hospitals of Geneva, Geneva, Switzerland
7. ⁷Department of Microbiology, The Royal Children's Hospital, Parkville, Victoria, Australia
8. ⁸Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute, Parkville, Victoria, Australia
9. ⁹Department of Allergy and Immunology, The Royal Children's Hospital, Parkville, Victoria, Australia
10. ¹⁰Department of Clinical Pharmacology, Royal Children's Hospital, Parkville, Victoria, Australia
11. ¹¹Department of Infectious Diseases, The Royal Children's Hospital, Melbourne, Victoria, Australia

1. Correspondence to Dr Amanda L Wilkins; amanda.wilkins{at}rch.org.au

• Allergy
• Child Health
• Paediatrics

• Allergy
• Child Health
• Paediatrics

Footnotes

• Contributors ALW conceptualised and designed the study, acquired, analysed and interpreted the data for the work and drafted the initial manuscript. AG conceptualised and designed the study and assisted in drafting of the initial manuscript. SK, KW and SC all contributed substantially to data acquisition and reviewed and revised the manuscript critically for important intellectual content. LFP, SD and NC all contributed substantially to data analysis and interpretation of data for the work and reviewed and revised the manuscript critically for important intellectual content. Guarantors are ALW and AG.

• Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

• Competing interests None declared.

• Provenance and peer review Not commissioned; externally peer reviewed.

• Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.

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